The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad

Intracellular records were made from fibers in the A-V conducting system of isolated toad hearts. The A-V region was perfused with Ringer's solution of various K and Na concentrations. Resting potential in 2.8 mM [K](o) was about 60 mv. Over the range 0.28 to 28 mM, resting potential diminished...

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Detalles Bibliográficos
Autores principales: Kanno, Tomio, Matsuda, Kojiro
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1966
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225646/
https://www.ncbi.nlm.nih.gov/pubmed/11526826
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author Kanno, Tomio
Matsuda, Kojiro
author_facet Kanno, Tomio
Matsuda, Kojiro
author_sort Kanno, Tomio
collection PubMed
description Intracellular records were made from fibers in the A-V conducting system of isolated toad hearts. The A-V region was perfused with Ringer's solution of various K and Na concentrations. Resting potential in 2.8 mM [K](o) was about 60 mv. Over the range 0.28 to 28 mM, resting potential diminished with increasing [K](o). Spontaneous action potentials appeared when [K](o) was increased to 11.2 mM, and when resting potential had fallen to about 40 to 50 mv. Changes in [Na](o) over the range 22 to 110 mM had a little effect on resting potential, but there was a linear relation between the peak value of the action potential and log [Na](o) Wenckebach periodicity was observed when [Na](o) was lowered.
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spelling pubmed-22256462008-04-23 The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad Kanno, Tomio Matsuda, Kojiro J Gen Physiol Article Intracellular records were made from fibers in the A-V conducting system of isolated toad hearts. The A-V region was perfused with Ringer's solution of various K and Na concentrations. Resting potential in 2.8 mM [K](o) was about 60 mv. Over the range 0.28 to 28 mM, resting potential diminished with increasing [K](o). Spontaneous action potentials appeared when [K](o) was increased to 11.2 mM, and when resting potential had fallen to about 40 to 50 mv. Changes in [Na](o) over the range 22 to 110 mM had a little effect on resting potential, but there was a linear relation between the peak value of the action potential and log [Na](o) Wenckebach periodicity was observed when [Na](o) was lowered. The Rockefeller University Press 1966-11-01 /pmc/articles/PMC2225646/ /pubmed/11526826 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kanno, Tomio
Matsuda, Kojiro
The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title_full The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title_fullStr The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title_full_unstemmed The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title_short The Effects of External Sodium and Potassium Concentration on the Membrane Potential of Atrioventricular Fibers of the Toad
title_sort effects of external sodium and potassium concentration on the membrane potential of atrioventricular fibers of the toad
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225646/
https://www.ncbi.nlm.nih.gov/pubmed/11526826
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