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Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)

When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not b...

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Detalles Bibliográficos
Autores principales: Holloszy, John O., Narahara, H. T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225682/
https://www.ncbi.nlm.nih.gov/pubmed/11526846
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author Holloszy, John O.
Narahara, H. T.
author_facet Holloszy, John O.
Narahara, H. T.
author_sort Holloszy, John O.
collection PubMed
description When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not be intimately related to the depolarization phase of the tissue response. Contractures that were elicited by exposing the muscles to a high concentration of K(+) were also associated with an increased permeability to sugar. As the concentration of (45)Ca in the medium was raised, more (45)Ca entered the muscles during potassium contractures, and the contractures lasted longer, in agreement with the observations of other investigators. There was also a greater change in permeability to sugar when potassium contractures were elicited in the presence of higher concentrations of Ca(++). The possibility that the enhanced permeability to sugar may be related to changes in the intracellular concentration of Ca(++) is discussed.
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spelling pubmed-22256822008-04-23 Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) Holloszy, John O. Narahara, H. T. J Gen Physiol Article When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not be intimately related to the depolarization phase of the tissue response. Contractures that were elicited by exposing the muscles to a high concentration of K(+) were also associated with an increased permeability to sugar. As the concentration of (45)Ca in the medium was raised, more (45)Ca entered the muscles during potassium contractures, and the contractures lasted longer, in agreement with the observations of other investigators. There was also a greater change in permeability to sugar when potassium contractures were elicited in the presence of higher concentrations of Ca(++). The possibility that the enhanced permeability to sugar may be related to changes in the intracellular concentration of Ca(++) is discussed. The Rockefeller University Press 1967-01-01 /pmc/articles/PMC2225682/ /pubmed/11526846 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Holloszy, John O.
Narahara, H. T.
Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title_full Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title_fullStr Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title_full_unstemmed Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title_short Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
title_sort enhanced permeability to sugar associated with muscle contraction : studies of the role of ca(++)
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225682/
https://www.ncbi.nlm.nih.gov/pubmed/11526846
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