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Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++)
When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not b...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1967
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225682/ https://www.ncbi.nlm.nih.gov/pubmed/11526846 |
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author | Holloszy, John O. Narahara, H. T. |
author_facet | Holloszy, John O. Narahara, H. T. |
author_sort | Holloszy, John O. |
collection | PubMed |
description | When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not be intimately related to the depolarization phase of the tissue response. Contractures that were elicited by exposing the muscles to a high concentration of K(+) were also associated with an increased permeability to sugar. As the concentration of (45)Ca in the medium was raised, more (45)Ca entered the muscles during potassium contractures, and the contractures lasted longer, in agreement with the observations of other investigators. There was also a greater change in permeability to sugar when potassium contractures were elicited in the presence of higher concentrations of Ca(++). The possibility that the enhanced permeability to sugar may be related to changes in the intracellular concentration of Ca(++) is discussed. |
format | Text |
id | pubmed-2225682 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1967 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22256822008-04-23 Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) Holloszy, John O. Narahara, H. T. J Gen Physiol Article When contractures were induced in isolated frog sartorius muscles with 4 mM caffeine, there was an increase in permeability of the muscle cells to 3-methylglucose. This observation suggests that the changes in permeability to sugar that are known to occur in electrically stimulated muscles may not be intimately related to the depolarization phase of the tissue response. Contractures that were elicited by exposing the muscles to a high concentration of K(+) were also associated with an increased permeability to sugar. As the concentration of (45)Ca in the medium was raised, more (45)Ca entered the muscles during potassium contractures, and the contractures lasted longer, in agreement with the observations of other investigators. There was also a greater change in permeability to sugar when potassium contractures were elicited in the presence of higher concentrations of Ca(++). The possibility that the enhanced permeability to sugar may be related to changes in the intracellular concentration of Ca(++) is discussed. The Rockefeller University Press 1967-01-01 /pmc/articles/PMC2225682/ /pubmed/11526846 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Holloszy, John O. Narahara, H. T. Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title | Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title_full | Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title_fullStr | Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title_full_unstemmed | Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title_short | Enhanced Permeability to Sugar Associated with Muscle Contraction : Studies of the role of Ca(++) |
title_sort | enhanced permeability to sugar associated with muscle contraction : studies of the role of ca(++) |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225682/ https://www.ncbi.nlm.nih.gov/pubmed/11526846 |
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