Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin

The permeability of frog skin to a series of nonelectrolytes (thiourea, urea, mannitol, and sucrose) under the influence of 2.5 times normal osmolarity in the outer bathing solution has been investigated. Although the flux of the tracer nonelectrolytes across the skin in either direction is greatly...

Descripción completa

Detalles Bibliográficos
Autores principales: Franz, T. J., Van Bruggen, J. T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225698/
https://www.ncbi.nlm.nih.gov/pubmed/6034510
_version_ 1782149687159029760
author Franz, T. J.
Van Bruggen, J. T.
author_facet Franz, T. J.
Van Bruggen, J. T.
author_sort Franz, T. J.
collection PubMed
description The permeability of frog skin to a series of nonelectrolytes (thiourea, urea, mannitol, and sucrose) under the influence of 2.5 times normal osmolarity in the outer bathing solution has been investigated. Although the flux of the tracer nonelectrolytes across the skin in either direction is greatly increased by hyperosmolarity, the influx is found to be increased to a significantly greater extent than the outflux. Flux ratios as high as 3:1 can be observed. The net inward movement of the nonelectrolyte proceeds in spite of a sizeable bulk flow of water in the opposite direction. Possible driving forces for this phenomenon are discussed.
format Text
id pubmed-2225698
institution National Center for Biotechnology Information
language English
publishDate 1967
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22256982008-04-23 Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin Franz, T. J. Van Bruggen, J. T. J Gen Physiol Article The permeability of frog skin to a series of nonelectrolytes (thiourea, urea, mannitol, and sucrose) under the influence of 2.5 times normal osmolarity in the outer bathing solution has been investigated. Although the flux of the tracer nonelectrolytes across the skin in either direction is greatly increased by hyperosmolarity, the influx is found to be increased to a significantly greater extent than the outflux. Flux ratios as high as 3:1 can be observed. The net inward movement of the nonelectrolyte proceeds in spite of a sizeable bulk flow of water in the opposite direction. Possible driving forces for this phenomenon are discussed. The Rockefeller University Press 1967-03-01 /pmc/articles/PMC2225698/ /pubmed/6034510 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Franz, T. J.
Van Bruggen, J. T.
Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title_full Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title_fullStr Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title_full_unstemmed Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title_short Hyperosmolarity and the Net Transport of Nonelectrolytes in Frog Skin
title_sort hyperosmolarity and the net transport of nonelectrolytes in frog skin
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225698/
https://www.ncbi.nlm.nih.gov/pubmed/6034510
work_keys_str_mv AT franztj hyperosmolarityandthenettransportofnonelectrolytesinfrogskin
AT vanbruggenjt hyperosmolarityandthenettransportofnonelectrolytesinfrogskin

Ejemplares similares