Removal of Potassium Negative Resistance in Perfused Squid Giant Axons

Squid giant axons, internally and externally perfused with solutions having potassium as the only cation, exhibit an approximately linear steady-state current-voltage relation. When small amounts of calcium and magnesium are present in the external potassium solution, the current-voltage curve is ma...

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Detalles Bibliográficos
Autores principales: Lecar, Harold, Ehrenstein, Gerald, Binstock, Leonard, Taylor, Robert E.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1967
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225733/
https://www.ncbi.nlm.nih.gov/pubmed/6034755
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author Lecar, Harold
Ehrenstein, Gerald
Binstock, Leonard
Taylor, Robert E.
author_facet Lecar, Harold
Ehrenstein, Gerald
Binstock, Leonard
Taylor, Robert E.
author_sort Lecar, Harold
collection PubMed
description Squid giant axons, internally and externally perfused with solutions having potassium as the only cation, exhibit an approximately linear steady-state current-voltage relation. When small amounts of calcium and magnesium are present in the external potassium solution, the current-voltage curve is markedly nonlinear, exhibiting the rectification and negative resistance which have been observed for intact axons in isosmotic potassium solutions. The effects of perfusion and removal of external divalent cations are interpreted in terms of two components of current, a linear component and a nonlinear time-varying component. The former is increased and the latter diminished by the removal of the external divalent cations.
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spelling pubmed-22257332008-04-23 Removal of Potassium Negative Resistance in Perfused Squid Giant Axons Lecar, Harold Ehrenstein, Gerald Binstock, Leonard Taylor, Robert E. J Gen Physiol Article Squid giant axons, internally and externally perfused with solutions having potassium as the only cation, exhibit an approximately linear steady-state current-voltage relation. When small amounts of calcium and magnesium are present in the external potassium solution, the current-voltage curve is markedly nonlinear, exhibiting the rectification and negative resistance which have been observed for intact axons in isosmotic potassium solutions. The effects of perfusion and removal of external divalent cations are interpreted in terms of two components of current, a linear component and a nonlinear time-varying component. The former is increased and the latter diminished by the removal of the external divalent cations. The Rockefeller University Press 1967-07-01 /pmc/articles/PMC2225733/ /pubmed/6034755 Text en Copyright © 1967 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Lecar, Harold
Ehrenstein, Gerald
Binstock, Leonard
Taylor, Robert E.
Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title_full Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title_fullStr Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title_full_unstemmed Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title_short Removal of Potassium Negative Resistance in Perfused Squid Giant Axons
title_sort removal of potassium negative resistance in perfused squid giant axons
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225733/
https://www.ncbi.nlm.nih.gov/pubmed/6034755
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