Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine

Continuous culture of coli 12λ, P22, 600-434, 600-21, and 600-299 in the presence of triethylenemelamine (TEM) results in the appearance of a new virulent virus which attacks the parent culture. N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) is effective with 600-21 and ultraviolet light with 12λ...

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Autor principal: Northrop, John H.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1968
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225795/
https://www.ncbi.nlm.nih.gov/pubmed/4913699
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author Northrop, John H.
author_facet Northrop, John H.
author_sort Northrop, John H.
collection PubMed
description Continuous culture of coli 12λ, P22, 600-434, 600-21, and 600-299 in the presence of triethylenemelamine (TEM) results in the appearance of a new virulent virus which attacks the parent culture. N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) is effective with 600-21 and ultraviolet light with 12λ and 600-21. The cultures which produce the virulent virus continue to do so indefinitely in the absence of the mutagen, but are not lysogenic for the virus. Most of the cells in such cultures are resistant to the virus and do not produce any, but there are a few mutant cells sensitive to the virus and the virus multiplies by infection of these sensitive mutants.
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spelling pubmed-22257952008-04-23 Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine Northrop, John H. J Gen Physiol Article Continuous culture of coli 12λ, P22, 600-434, 600-21, and 600-299 in the presence of triethylenemelamine (TEM) results in the appearance of a new virulent virus which attacks the parent culture. N-Methyl-N'-nitro-N-nitrosoguanidine (MNNG) is effective with 600-21 and ultraviolet light with 12λ and 600-21. The cultures which produce the virulent virus continue to do so indefinitely in the absence of the mutagen, but are not lysogenic for the virus. Most of the cells in such cultures are resistant to the virus and do not produce any, but there are a few mutant cells sensitive to the virus and the virus multiplies by infection of these sensitive mutants. The Rockefeller University Press 1968-07-01 /pmc/articles/PMC2225795/ /pubmed/4913699 Text en Copyright © 1968 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Northrop, John H.
Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title_full Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title_fullStr Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title_full_unstemmed Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title_short Appearance of Virulent Bacteriophages in Lysogenic E. coli Cultures after Prolonged Growth in the Presence of Triethylenemelamine
title_sort appearance of virulent bacteriophages in lysogenic e. coli cultures after prolonged growth in the presence of triethylenemelamine
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225795/
https://www.ncbi.nlm.nih.gov/pubmed/4913699
work_keys_str_mv AT northropjohnh appearanceofvirulentbacteriophagesinlysogenicecoliculturesafterprolongedgrowthinthepresenceoftriethylenemelamine

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