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Double-Stranded Polynucleotides as Interferon Inducers

A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, resistance to enzymatic degradation, and molecular si...

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Detalles Bibliográficos
Autores principales: Field, A. K., Tytell, A. A., Lampson, G. P., Nemes, M. M., Hilleman, M. R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225865/
https://www.ncbi.nlm.nih.gov/pubmed/19873677
Descripción
Sumario:A discussion of factors considered influential in making a polynucleotide an efficient inducer of interferon was presented. These factors were double-strandedness of the polynucleotides, the sugar moiety of the polynucleotides, thermal stability, resistance to enzymatic degradation, and molecular size of the polynucloetides. Recent developments concerning interferon induction during virus infection were also discussed.