Interferon and Interferon Inducers in the Treatment of Malignancies

The mechanism of the antitumor action of polyinosinic-polycytidylic acid is probably multifaceted. The compound induces the synthesis of interferon, and interferon probably is active against some tumors. Poly I:poly C alters protein and RNA synthesis in tissue culture. It specifically inhibits such...

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Detalles Bibliográficos
Autores principales: Levy, Hilton B., Riley, Freddie, Margolis, Sam
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Interferon and Interferon Inducers in Disease
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225867/
https://www.ncbi.nlm.nih.gov/pubmed/19873670
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author Levy, Hilton B.
Riley, Freddie
Margolis, Sam
author_facet Levy, Hilton B.
Riley, Freddie
Margolis, Sam
author_sort Levy, Hilton B.
collection PubMed
description The mechanism of the antitumor action of polyinosinic-polycytidylic acid is probably multifaceted. The compound induces the synthesis of interferon, and interferon probably is active against some tumors. Poly I:poly C alters protein and RNA synthesis in tissue culture. It specifically inhibits such macromolecule synthesis in tumors in vivo, while having less inhibitory action on synthesis in normal organs, or it may actually enhance. Finally, poly I:poly C strongly enhances graft vs. host rejection mechanisms, which may play a role in the rejection of some tumors.
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spelling pubmed-22258672008-04-23 Interferon and Interferon Inducers in the Treatment of Malignancies Levy, Hilton B. Riley, Freddie Margolis, Sam J Gen Physiol Interferon and Interferon Inducers in Disease The mechanism of the antitumor action of polyinosinic-polycytidylic acid is probably multifaceted. The compound induces the synthesis of interferon, and interferon probably is active against some tumors. Poly I:poly C alters protein and RNA synthesis in tissue culture. It specifically inhibits such macromolecule synthesis in tumors in vivo, while having less inhibitory action on synthesis in normal organs, or it may actually enhance. Finally, poly I:poly C strongly enhances graft vs. host rejection mechanisms, which may play a role in the rejection of some tumors. The Rockefeller University Press 1970-07-01 /pmc/articles/PMC2225867/ /pubmed/19873670 Text en Copyright © 1970 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Interferon and Interferon Inducers in Disease
Levy, Hilton B.
Riley, Freddie
Margolis, Sam
Interferon and Interferon Inducers in the Treatment of Malignancies
title Interferon and Interferon Inducers in the Treatment of Malignancies
title_full Interferon and Interferon Inducers in the Treatment of Malignancies
title_fullStr Interferon and Interferon Inducers in the Treatment of Malignancies
title_full_unstemmed Interferon and Interferon Inducers in the Treatment of Malignancies
title_short Interferon and Interferon Inducers in the Treatment of Malignancies
title_sort interferon and interferon inducers in the treatment of malignancies
topic Interferon and Interferon Inducers in Disease
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225867/
https://www.ncbi.nlm.nih.gov/pubmed/19873670
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AT rileyfreddie interferonandinterferoninducersinthetreatmentofmalignancies
AT margolissam interferonandinterferoninducersinthetreatmentofmalignancies

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