The Uptake of a Labeled Double-Stranded Polynucleotide by Cultured Rabbit Kidney Cells: An Electron Microscopic Study

Polyribocytidylate-(3)H-polyriboinosinate (rC-(3)H:rI) enters cultured rabbit kidney cells from the surrounding medium within ½ hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions. Subsequently, the grai...

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Detalles Bibliográficos
Autores principales: Prose, Philip H., Friedman-Kien, Alvin, Vilček, Jan
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1970
Materias:
Interferon Induction ⋅ II
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225873/
https://www.ncbi.nlm.nih.gov/pubmed/19873679
Descripción
Sumario:Polyribocytidylate-(3)H-polyriboinosinate (rC-(3)H:rI) enters cultured rabbit kidney cells from the surrounding medium within ½ hr after exposure. Grains are found in the cytoplasm, nucleus, and nucleolus. At 2 hr, grains are localized predominantly over the nucleolar regions. Subsequently, the grains in the nucleus become dispersed. A specific receptor site for the initiation of interferon production was not revealed.

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