Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid

Insulin in low concentrations inhibits the uptake of Ca(++) by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca(++) adsorbed to the monolayer. These effects of insulin are more pronounced at higher insulin concentrations. Evidence is presente...

Descripción completa

Detalles Bibliográficos
Autores principales: Kafka, Marian S., Pak, Charles Y. C.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1969
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225915/
https://www.ncbi.nlm.nih.gov/pubmed/5792362
_version_ 1782149737737093120
author Kafka, Marian S.
Pak, Charles Y. C.
author_facet Kafka, Marian S.
Pak, Charles Y. C.
author_sort Kafka, Marian S.
collection PubMed
description Insulin in low concentrations inhibits the uptake of Ca(++) by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca(++) adsorbed to the monolayer. These effects of insulin are more pronounced at higher insulin concentrations. Evidence is presented that a relatively intact insulin molecule competes with Ca(++) for the free phosphate group of the monolayer. Albumin has a slight inhibitory action on calcium uptake and parathyroid hormone has no observable action on calcium uptake or release.
format Text
id pubmed-2225915
institution National Center for Biotechnology Information
language English
publishDate 1969
publisher The Rockefeller University Press
record_format MEDLINE/PubMed
spelling pubmed-22259152008-04-23 Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid Kafka, Marian S. Pak, Charles Y. C. J Gen Physiol Article Insulin in low concentrations inhibits the uptake of Ca(++) by the monooctadecyl (stearyl) phosphate monolayer (at air-water interface) and facilitates the release of Ca(++) adsorbed to the monolayer. These effects of insulin are more pronounced at higher insulin concentrations. Evidence is presented that a relatively intact insulin molecule competes with Ca(++) for the free phosphate group of the monolayer. Albumin has a slight inhibitory action on calcium uptake and parathyroid hormone has no observable action on calcium uptake or release. The Rockefeller University Press 1969-07-01 /pmc/articles/PMC2225915/ /pubmed/5792362 Text en Copyright © 1969 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Kafka, Marian S.
Pak, Charles Y. C.
Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title_full Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title_fullStr Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title_full_unstemmed Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title_short Effects of Polypeptide and Protein Hormones on Lipid Monolayers : I. Effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
title_sort effects of polypeptide and protein hormones on lipid monolayers : i. effect of insulin and parathyroid hormone on monomolecular films of monooctadecyl phosphate and stearic acid
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2225915/
https://www.ncbi.nlm.nih.gov/pubmed/5792362
work_keys_str_mv AT kafkamarians effectsofpolypeptideandproteinhormonesonlipidmonolayersieffectofinsulinandparathyroidhormoneonmonomolecularfilmsofmonooctadecylphosphateandstearicacid
AT pakcharlesyc effectsofpolypeptideandproteinhormonesonlipidmonolayersieffectofinsulinandparathyroidhormoneonmonomolecularfilmsofmonooctadecylphosphateandstearicacid

Ejemplares similares