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Measurement of the Permeability of Biological Membranes Application to the glomerular wall
The transport equation describing the flow of solute across a membrane has been modified on the basis of theoretical studies calculating the drag of a sphere moving in a viscous liquid undergoing Poiseuille flow inside a cylinder. It is shown that different frictional resistance terms should be intr...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1973
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226123/ https://www.ncbi.nlm.nih.gov/pubmed/4755850 |
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author | Verniory, A. Du Bois, R. Decoodt, P. Gassee, J. P. Lambert, P. P. |
author_facet | Verniory, A. Du Bois, R. Decoodt, P. Gassee, J. P. Lambert, P. P. |
author_sort | Verniory, A. |
collection | PubMed |
description | The transport equation describing the flow of solute across a membrane has been modified on the basis of theoretical studies calculating the drag of a sphere moving in a viscous liquid undergoing Poiseuille flow inside a cylinder. It is shown that different frictional resistance terms should be introduced to calculate the contributions of diffusion and convection. New sieving equations are derived to calculate r and A(p)/Δx (respectively, the pore radius and the total area of the pores per unit of path length). These equations provide a better agreement than the older formulas between the calculated and the experimental glomerular sieving coefficients for [(125)I]polyvinylpyrrolidone (PVP) fractions with a mean equivalent radius between 19 and 37 Å. From r and A(p)/Δx, the mean effective glomerular filtration pressure has been calculated, applying Poiseuille's law. A value of 15.4 mm Hg has been derived from the mean sieving curve obtained from 23 experiments performed on normal anesthetized dogs. |
format | Text |
id | pubmed-2226123 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1973 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22261232008-04-23 Measurement of the Permeability of Biological Membranes Application to the glomerular wall Verniory, A. Du Bois, R. Decoodt, P. Gassee, J. P. Lambert, P. P. J Gen Physiol Article The transport equation describing the flow of solute across a membrane has been modified on the basis of theoretical studies calculating the drag of a sphere moving in a viscous liquid undergoing Poiseuille flow inside a cylinder. It is shown that different frictional resistance terms should be introduced to calculate the contributions of diffusion and convection. New sieving equations are derived to calculate r and A(p)/Δx (respectively, the pore radius and the total area of the pores per unit of path length). These equations provide a better agreement than the older formulas between the calculated and the experimental glomerular sieving coefficients for [(125)I]polyvinylpyrrolidone (PVP) fractions with a mean equivalent radius between 19 and 37 Å. From r and A(p)/Δx, the mean effective glomerular filtration pressure has been calculated, applying Poiseuille's law. A value of 15.4 mm Hg has been derived from the mean sieving curve obtained from 23 experiments performed on normal anesthetized dogs. The Rockefeller University Press 1973-10-01 /pmc/articles/PMC2226123/ /pubmed/4755850 Text en Copyright © 1973 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Article Verniory, A. Du Bois, R. Decoodt, P. Gassee, J. P. Lambert, P. P. Measurement of the Permeability of Biological Membranes Application to the glomerular wall |
title | Measurement of the Permeability of Biological Membranes Application to the glomerular wall
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title_full | Measurement of the Permeability of Biological Membranes Application to the glomerular wall
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title_fullStr | Measurement of the Permeability of Biological Membranes Application to the glomerular wall
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title_full_unstemmed | Measurement of the Permeability of Biological Membranes Application to the glomerular wall
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title_short | Measurement of the Permeability of Biological Membranes Application to the glomerular wall
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title_sort | measurement of the permeability of biological membranes application to the glomerular wall |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226123/ https://www.ncbi.nlm.nih.gov/pubmed/4755850 |
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