Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors

Ocular oxygen concentration by the process of counter current multiplication in rainbow trout (Salmo gairdneri) was rapidly suppressed after intraperitoneal injections of the carbonic anhydrase inhibitor CL-11,366. The rapidity with which this drug acted suggested a short circuiting of the choroidal...

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Autores principales: Fairbanks, Michael B., Hoffert, J. Russell, Fromm, Paul O.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1974
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226179/
https://www.ncbi.nlm.nih.gov/pubmed/4415760
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author Fairbanks, Michael B.
Hoffert, J. Russell
Fromm, Paul O.
author_facet Fairbanks, Michael B.
Hoffert, J. Russell
Fromm, Paul O.
author_sort Fairbanks, Michael B.
collection PubMed
description Ocular oxygen concentration by the process of counter current multiplication in rainbow trout (Salmo gairdneri) was rapidly suppressed after intraperitoneal injections of the carbonic anhydrase inhibitor CL-11,366. The rapidity with which this drug acted suggested a short circuiting of the choroidal rete mirabile. A comparison was made between the time after injection of inhibitor at which oxygen concentrating ability was lost to the time after injection of inhibitor at which its presence in red blood cells, choroidal rete, pseudobranch, and retinal tissue was first noted. A scheme for the possible role of carbonic anhydrase from each of these tissues in the process of ocular oxygen concentration is given.
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spelling pubmed-22261792008-04-23 Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors Fairbanks, Michael B. Hoffert, J. Russell Fromm, Paul O. J Gen Physiol Article Ocular oxygen concentration by the process of counter current multiplication in rainbow trout (Salmo gairdneri) was rapidly suppressed after intraperitoneal injections of the carbonic anhydrase inhibitor CL-11,366. The rapidity with which this drug acted suggested a short circuiting of the choroidal rete mirabile. A comparison was made between the time after injection of inhibitor at which oxygen concentrating ability was lost to the time after injection of inhibitor at which its presence in red blood cells, choroidal rete, pseudobranch, and retinal tissue was first noted. A scheme for the possible role of carbonic anhydrase from each of these tissues in the process of ocular oxygen concentration is given. The Rockefeller University Press 1974-09-01 /pmc/articles/PMC2226179/ /pubmed/4415760 Text en Copyright © 1974 by The Rockefeller University Press This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Article
Fairbanks, Michael B.
Hoffert, J. Russell
Fromm, Paul O.
Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title_full Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title_fullStr Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title_full_unstemmed Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title_short Short Circuiting of the Ocular Oxygen Concentrating Mechanism in the Teleost Salmo gairdneri Using Carbonic Anhydrase Inhibitors
title_sort short circuiting of the ocular oxygen concentrating mechanism in the teleost salmo gairdneri using carbonic anhydrase inhibitors
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226179/
https://www.ncbi.nlm.nih.gov/pubmed/4415760
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