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Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP)
The organic cation 2,4,6-triaminopyrimidinium (TAP), which blocks the tight junction channels for cation permeability across gallbladder, also inhibits gallbladder permeability (P) to urea and glycerol without significantly affecting P to Cl(-), sucrose, 1,7-heptanediol, or water (osmotic or diffusi...
Formato: | Texto |
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Lenguaje: | English |
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The Rockefeller University Press
1975
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226189/ https://www.ncbi.nlm.nih.gov/pubmed/1171931 |
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collection | PubMed |
description | The organic cation 2,4,6-triaminopyrimidinium (TAP), which blocks the tight junction channels for cation permeability across gallbladder, also inhibits gallbladder permeability (P) to urea and glycerol without significantly affecting P to Cl(-), sucrose, 1,7-heptanediol, or water (osmotic or diffusional permeabilities). These effects together with the comparisons of P's in frog with P's in rabbit gallbladder suggest that sucrose migrates exclusively through the leakage pathway (through where Cl(-) permeates), and that urea and glycerol permeate in addition through both, the tight junction channels for cations and a polar pathway at the cell membranes. Water and 1,7-heptanediol probably permeate mainly through the epithelial cell membranes. |
format | Text |
id | pubmed-2226189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1975 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22261892008-04-23 Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) J Gen Physiol Articles The organic cation 2,4,6-triaminopyrimidinium (TAP), which blocks the tight junction channels for cation permeability across gallbladder, also inhibits gallbladder permeability (P) to urea and glycerol without significantly affecting P to Cl(-), sucrose, 1,7-heptanediol, or water (osmotic or diffusional permeabilities). These effects together with the comparisons of P's in frog with P's in rabbit gallbladder suggest that sucrose migrates exclusively through the leakage pathway (through where Cl(-) permeates), and that urea and glycerol permeate in addition through both, the tight junction channels for cations and a polar pathway at the cell membranes. Water and 1,7-heptanediol probably permeate mainly through the epithelial cell membranes. The Rockefeller University Press 1975-07-01 /pmc/articles/PMC2226189/ /pubmed/1171931 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/). |
spellingShingle | Articles Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title | Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title_full | Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title_fullStr | Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title_full_unstemmed | Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title_short | Routes of nonelectrolyte permeability in gallbladder. Effects of 2,4,6- triaminopyrimidinium (TAP) |
title_sort | routes of nonelectrolyte permeability in gallbladder. effects of 2,4,6- triaminopyrimidinium (tap) |
topic | Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2226189/ https://www.ncbi.nlm.nih.gov/pubmed/1171931 |