Design and mechanism of action of a novel cytotoxic 1,2,3-triazene-containing heterocycle, 3,5-dimethyl-pyrido-1,2,3,5-tetrazepin-4-one (PYRZ), in the human epithelial ovarian cancer cell line NIH:OVCAR-3 in vitro.

The mechanism of action of the novel heterocycle 3,5-dimethyl-pyrido-1,2,3,5-tetrazepin-4-one (PYRZ), structurally related to temozolomide, was studied in the human ovarian tumour cell line OVCAR-3. Our results showed that, despite its marked structural similarities to temozolomide, PYRZ presents pr...

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Detalles Bibliográficos
Autores principales: Jean-Claude, B. J., Mustafa, A., Cetateanu, N. D., Damian, Z., De Marte, J., Yen, R., Vasilescu, D., Chan, T. H., Leyland-Jones, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2227996/
https://www.ncbi.nlm.nih.gov/pubmed/9275023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2227996/
https://www.ncbi.nlm.nih.gov/pubmed/9275023

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