Classical gene amplifications in human breast cancer are not associated with distant solid metastases.

To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of ge...

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Autores principales: Driouch, K., Champème, M. H., Beuzelin, M., Bièche, I., Lidereau, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228028/
https://www.ncbi.nlm.nih.gov/pubmed/9310246
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author Driouch, K.
Champème, M. H.
Beuzelin, M.
Bièche, I.
Lidereau, R.
author_facet Driouch, K.
Champème, M. H.
Beuzelin, M.
Bièche, I.
Lidereau, R.
author_sort Driouch, K.
collection PubMed
description To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression. IMAGES:
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spelling pubmed-22280282009-09-10 Classical gene amplifications in human breast cancer are not associated with distant solid metastases. Driouch, K. Champème, M. H. Beuzelin, M. Bièche, I. Lidereau, R. Br J Cancer Research Article To determine the relationship between breast cancer progression and gene amplification, we screened 62 distant metastases and 122 primary breast tumours for the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region. Surprisingly, solid metastases showed an absence of gene amplification. These results suggest that the amplification of the proto-oncogenes MYC and ERBB2 and the 11q13 chromosomal region seem to be involved mainly in the genesis of the primary breast tumour rather than its progression. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228028/ /pubmed/9310246 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Driouch, K.
Champème, M. H.
Beuzelin, M.
Bièche, I.
Lidereau, R.
Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title_full Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title_fullStr Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title_full_unstemmed Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title_short Classical gene amplifications in human breast cancer are not associated with distant solid metastases.
title_sort classical gene amplifications in human breast cancer are not associated with distant solid metastases.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228028/
https://www.ncbi.nlm.nih.gov/pubmed/9310246
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