A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.

Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P...

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Detalles Bibliográficos
Autores principales: McMillan, D. C., O'Gorman, P., Fearon, K. C., McArdle, C. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228041/
https://www.ncbi.nlm.nih.gov/pubmed/9310247
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author McMillan, D. C.
O'Gorman, P.
Fearon, K. C.
McArdle, C. S.
author_facet McMillan, D. C.
O'Gorman, P.
Fearon, K. C.
McArdle, C. S.
author_sort McMillan, D. C.
collection PubMed
description Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study.
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spelling pubmed-22280412009-09-10 A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients. McMillan, D. C. O'Gorman, P. Fearon, K. C. McArdle, C. S. Br J Cancer Research Article Advanced gastrointestinal cancer patients with weight loss and an acute-phase response (n = 15) were given megestrol acetate (480 mg day(-1)) and ibuprofen (1200 mg day(-1)) for 6 weeks. Overall, there was an increase in body weight (P = 0.01) and a reduction in C-reactive protein concentrations (P = 0.02), with no change in total body water (P = 0.24) over this period. This regimen may be an effective non-toxic treatment for cancer cachexia and is worthy of further study. Nature Publishing Group 1997 /pmc/articles/PMC2228041/ /pubmed/9310247 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McMillan, D. C.
O'Gorman, P.
Fearon, K. C.
McArdle, C. S.
A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title_full A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title_fullStr A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title_full_unstemmed A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title_short A pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
title_sort pilot study of megestrol acetate and ibuprofen in the treatment of cachexia in gastrointestinal cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228041/
https://www.ncbi.nlm.nih.gov/pubmed/9310247
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