Low frequency of allelic loss in skin tumours from immunosuppressed individuals.

Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed in...

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Autores principales: Rehman, I., Quinn, A. G., Takata, M., Taylor, A. E., Rees, J. L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228045/
https://www.ncbi.nlm.nih.gov/pubmed/9310241
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author Rehman, I.
Quinn, A. G.
Takata, M.
Taylor, A. E.
Rees, J. L.
author_facet Rehman, I.
Quinn, A. G.
Takata, M.
Taylor, A. E.
Rees, J. L.
author_sort Rehman, I.
collection PubMed
description Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed individuals than in tumours from immunocompetent subjects [20 out of 148 (14%) vs 157 out of 428 (37%); P< 0.0001]. These results suggest that tumours in immunosuppressed individuals have a different molecular pathogenesis. IMAGES:
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spelling pubmed-22280452009-09-10 Low frequency of allelic loss in skin tumours from immunosuppressed individuals. Rehman, I. Quinn, A. G. Takata, M. Taylor, A. E. Rees, J. L. Br J Cancer Research Article Organ transplant recipients receiving immunosuppression show a dramatically increased risk of non-melanoma skin cancer. The cause of this increase is not known. We report that the rate of loss of heterozygosity (at all the loci we examined) was significantly lower in tumours from immunosuppressed individuals than in tumours from immunocompetent subjects [20 out of 148 (14%) vs 157 out of 428 (37%); P< 0.0001]. These results suggest that tumours in immunosuppressed individuals have a different molecular pathogenesis. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228045/ /pubmed/9310241 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Rehman, I.
Quinn, A. G.
Takata, M.
Taylor, A. E.
Rees, J. L.
Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title_full Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title_fullStr Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title_full_unstemmed Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title_short Low frequency of allelic loss in skin tumours from immunosuppressed individuals.
title_sort low frequency of allelic loss in skin tumours from immunosuppressed individuals.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228045/
https://www.ncbi.nlm.nih.gov/pubmed/9310241
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