Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.

hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuc...

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Autores principales: Fink, D., Nebel, S., Aebi, S., Zheng, H., Kim, H. K., Christen, R. D., Howell, S. B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228055/
https://www.ncbi.nlm.nih.gov/pubmed/9328148
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author Fink, D.
Nebel, S.
Aebi, S.
Zheng, H.
Kim, H. K.
Christen, R. D.
Howell, S. B.
author_facet Fink, D.
Nebel, S.
Aebi, S.
Zheng, H.
Kim, H. K.
Christen, R. D.
Howell, S. B.
author_sort Fink, D.
collection PubMed
description hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair. IMAGES:
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spelling pubmed-22280552009-09-10 Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues. Fink, D. Nebel, S. Aebi, S. Zheng, H. Kim, H. K. Christen, R. D. Howell, S. B. Br J Cancer Research Article hMLH1 and hPMS2 are part of the DNA mismatch repair complex. Mutations in these genes have been linked to hereditary non-polyposis colon cancer; they also occur in a variety of sporadic cancers. Western blot analysis and immunohistochemistry demonstrated that hMLH1 and hPMS2 are widely expressed nuclear proteins with a distribution pattern very similar to that previously described for hMSH2. These observations showing similar localization of hMLH1 and hPMS2 with hMSH2 are consistent with the biochemical function of these proteins in DNA mismatch repair. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228055/ /pubmed/9328148 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Fink, D.
Nebel, S.
Aebi, S.
Zheng, H.
Kim, H. K.
Christen, R. D.
Howell, S. B.
Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title_full Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title_fullStr Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title_full_unstemmed Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title_short Expression of the DNA mismatch repair proteins hMLH1 and hPMS2 in normal human tissues.
title_sort expression of the dna mismatch repair proteins hmlh1 and hpms2 in normal human tissues.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228055/
https://www.ncbi.nlm.nih.gov/pubmed/9328148
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