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Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy.
The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic dis...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1997
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228056/ https://www.ncbi.nlm.nih.gov/pubmed/9328142 |
| _version_ | 1782149825952743424 |
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| author | Kelsey, K. T. Ross, D. Traver, R. D. Christiani, D. C. Zuo, Z. F. Spitz, M. R. Wang, M. Xu, X. Lee, B. K. Schwartz, B. S. Wiencke, J. K. |
| author_facet | Kelsey, K. T. Ross, D. Traver, R. D. Christiani, D. C. Zuo, Z. F. Spitz, M. R. Wang, M. Xu, X. Lee, B. K. Schwartz, B. S. Wiencke, J. K. |
| author_sort | Kelsey, K. T. |
| collection | PubMed |
| description | The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use. |
| format | Text |
| id | pubmed-2228056 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1997 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-22280562009-09-10 Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. Kelsey, K. T. Ross, D. Traver, R. D. Christiani, D. C. Zuo, Z. F. Spitz, M. R. Wang, M. Xu, X. Lee, B. K. Schwartz, B. S. Wiencke, J. K. Br J Cancer Research Article The NAD(P)H quinone oxidoreductase (NQO1:EC 1.6.99.2) is an important biotransformation enzyme system that is also known to metabolize important novel chemotherapeutic compounds. The gene that codes for this enzyme has recently been found to be polymorphic in humans. Here, we describe the ethnic distribution of the polymorphism and note that this may have implications for anti-tumour drug development and use. Nature Publishing Group 1997 /pmc/articles/PMC2228056/ /pubmed/9328142 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Kelsey, K. T. Ross, D. Traver, R. D. Christiani, D. C. Zuo, Z. F. Spitz, M. R. Wang, M. Xu, X. Lee, B. K. Schwartz, B. S. Wiencke, J. K. Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title | Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title_full | Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title_fullStr | Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title_full_unstemmed | Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title_short | Ethnic variation in the prevalence of a common NAD(P)H quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| title_sort | ethnic variation in the prevalence of a common nad(p)h quinone oxidoreductase polymorphism and its implications for anti-cancer chemotherapy. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228056/ https://www.ncbi.nlm.nih.gov/pubmed/9328142 |
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