Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.

Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by or...

Descripción completa

Detalles Bibliográficos
Autores principales: Kylmälä, T., Taube, T., Tammela, T. L., Risteli, L., Risteli, J., Elomaa, I.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228066/
https://www.ncbi.nlm.nih.gov/pubmed/9328156
_version_ 1782149828062478336
author Kylmälä, T.
Taube, T.
Tammela, T. L.
Risteli, L.
Risteli, J.
Elomaa, I.
author_facet Kylmälä, T.
Taube, T.
Tammela, T. L.
Risteli, L.
Risteli, J.
Elomaa, I.
author_sort Kylmälä, T.
collection PubMed
description Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by oral treatment (1.6 g day[-1]) for 12 months. Skeletal pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral administration only.
format Text
id pubmed-2228066
institution National Center for Biotechnology Information
language English
publishDate 1997
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-22280662009-09-10 Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer. Kylmälä, T. Taube, T. Tammela, T. L. Risteli, L. Risteli, J. Elomaa, I. Br J Cancer Research Article Fifty-seven patients with advanced prostate cancer resistant to first-line hormonal therapy were treated with estramustine and additionally randomized for treatment with clodronate or placebo. Clodronate treatment was started with 5 days intravenous administration (300 mg day[-1]) and followed by oral treatment (1.6 g day[-1]) for 12 months. Skeletal pain relief was only about 10% better in the clodronate than in the placebo group. The results do not support the superiority of combined intravenous and oral treatment with clodronate compared with oral administration only. Nature Publishing Group 1997 /pmc/articles/PMC2228066/ /pubmed/9328156 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kylmälä, T.
Taube, T.
Tammela, T. L.
Risteli, L.
Risteli, J.
Elomaa, I.
Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title_full Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title_fullStr Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title_full_unstemmed Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title_short Concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
title_sort concomitant i.v. and oral clodronate in the relief of bone pain--a double-blind placebo-controlled study in patients with prostate cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228066/
https://www.ncbi.nlm.nih.gov/pubmed/9328156
work_keys_str_mv AT kylmalat concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer
AT taubet concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer
AT tammelatl concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer
AT ristelil concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer
AT ristelij concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer
AT elomaai concomitantivandoralclodronateinthereliefofbonepainadoubleblindplacebocontrolledstudyinpatientswithprostatecancer

Ejemplares similares