PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.

Using RNA extracted from human tumour samples removed during surgery, we have analysed expression of mRNA for parathyroid hormone-related protein (PTHrP) and for the PTH/PTHrP receptor by RT-PCR in a panel of human breast and colon tumours. All but 1 of 18 breast tumour samples expressed PTHrP, wher...

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Detalles Bibliográficos
Autores principales: Carron, J. A., Fraser, W. D., Gallagher, J. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228095/
https://www.ncbi.nlm.nih.gov/pubmed/9376272
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author Carron, J. A.
Fraser, W. D.
Gallagher, J. A.
author_facet Carron, J. A.
Fraser, W. D.
Gallagher, J. A.
author_sort Carron, J. A.
collection PubMed
description Using RNA extracted from human tumour samples removed during surgery, we have analysed expression of mRNA for parathyroid hormone-related protein (PTHrP) and for the PTH/PTHrP receptor by RT-PCR in a panel of human breast and colon tumours. All but 1 of 18 breast tumour samples expressed PTHrP, whereas receptor expression was detected in 11 of these. Expression of the PTH/PTHrP receptor was found in three out of four metastatic lesions, including one sample in which no receptor was detected in the primary tumour. PTHrP expression was also detected in five colon tumours, and receptor expression detected in two of these. These results demonstrate that PTHrP and the PTHrP receptor are also co-expressed in breast tumours in vivo and provide further evidence that PTHrP may be an important autocrine/paracrine growth factor in breast cancer. IMAGES:
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spelling pubmed-22280952009-09-10 PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours. Carron, J. A. Fraser, W. D. Gallagher, J. A. Br J Cancer Research Article Using RNA extracted from human tumour samples removed during surgery, we have analysed expression of mRNA for parathyroid hormone-related protein (PTHrP) and for the PTH/PTHrP receptor by RT-PCR in a panel of human breast and colon tumours. All but 1 of 18 breast tumour samples expressed PTHrP, whereas receptor expression was detected in 11 of these. Expression of the PTH/PTHrP receptor was found in three out of four metastatic lesions, including one sample in which no receptor was detected in the primary tumour. PTHrP expression was also detected in five colon tumours, and receptor expression detected in two of these. These results demonstrate that PTHrP and the PTHrP receptor are also co-expressed in breast tumours in vivo and provide further evidence that PTHrP may be an important autocrine/paracrine growth factor in breast cancer. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228095/ /pubmed/9376272 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Carron, J. A.
Fraser, W. D.
Gallagher, J. A.
PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title_full PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title_fullStr PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title_full_unstemmed PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title_short PTHrP and the PTH/PTHrP receptor are co-expressed in human breast and colon tumours.
title_sort pthrp and the pth/pthrp receptor are co-expressed in human breast and colon tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228095/
https://www.ncbi.nlm.nih.gov/pubmed/9376272
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