Absence of methylation of CpG dinucleotides within the promoter of the breast cancer susceptibility gene BRCA2 in normal tissues and in breast and ovarian cancers.

Germline mutations of the BRCA2 gene on chromosome 13q12-q13 predispose to the development of early-onset breast cancer and ovarian cancer. Loss of heterozygosity detected using chromosome 13q markers in the vicinity of BRCA2 is observed in most cancers arising in carriers of germline BRCA2 mutation...

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Detalles Bibliográficos
Autores principales: Collins, N., Wooster, R., Stratton, M. R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228118/
https://www.ncbi.nlm.nih.gov/pubmed/9365162

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228118/
https://www.ncbi.nlm.nih.gov/pubmed/9365162

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