Molecular analysis of p21 and p27 genes in human pituitary adenomas.

Pituitary tumours develop at a high frequency in p27-knockout mice and retinoblastoma gene-knockout mice, which suggests that cell cycle regulatory genes, such as cyclin-dependent kinase inhibitor genes, are involved in the tumorigenesis of pituitary adenoma. Analysis of p21 and p27 gene abnormaliti...

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Autores principales: Ikeda, H., Yoshimoto, T., Shida, N.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228124/
https://www.ncbi.nlm.nih.gov/pubmed/9365157
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author Ikeda, H.
Yoshimoto, T.
Shida, N.
author_facet Ikeda, H.
Yoshimoto, T.
Shida, N.
author_sort Ikeda, H.
collection PubMed
description Pituitary tumours develop at a high frequency in p27-knockout mice and retinoblastoma gene-knockout mice, which suggests that cell cycle regulatory genes, such as cyclin-dependent kinase inhibitor genes, are involved in the tumorigenesis of pituitary adenoma. Analysis of p21 and p27 gene abnormalities in human pituitary adenoma was performed in 28 pituitary adenomas by polymerase chain reaction-single-strand conformational polymorphism. No point mutations were detected in these genes. As no abnormalities of the p21 and p27genes were observed, and if these genes are indeed inactivated, it is likely to be via transcriptional or translational defects. IMAGES:
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spelling pubmed-22281242009-09-10 Molecular analysis of p21 and p27 genes in human pituitary adenomas. Ikeda, H. Yoshimoto, T. Shida, N. Br J Cancer Research Article Pituitary tumours develop at a high frequency in p27-knockout mice and retinoblastoma gene-knockout mice, which suggests that cell cycle regulatory genes, such as cyclin-dependent kinase inhibitor genes, are involved in the tumorigenesis of pituitary adenoma. Analysis of p21 and p27 gene abnormalities in human pituitary adenoma was performed in 28 pituitary adenomas by polymerase chain reaction-single-strand conformational polymorphism. No point mutations were detected in these genes. As no abnormalities of the p21 and p27genes were observed, and if these genes are indeed inactivated, it is likely to be via transcriptional or translational defects. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228124/ /pubmed/9365157 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ikeda, H.
Yoshimoto, T.
Shida, N.
Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title_full Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title_fullStr Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title_full_unstemmed Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title_short Molecular analysis of p21 and p27 genes in human pituitary adenomas.
title_sort molecular analysis of p21 and p27 genes in human pituitary adenomas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228124/
https://www.ncbi.nlm.nih.gov/pubmed/9365157
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AT shidan molecularanalysisofp21andp27genesinhumanpituitaryadenomas

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