Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.

Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the...

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Detalles Bibliográficos
Autores principales: van Asperen, J., van Tellingen, O., Sparreboom, A., Schinkel, A. H., Borst, P., Nooijen, W. J., Beijnen, J. H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228133/
https://www.ncbi.nlm.nih.gov/pubmed/9365166
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author van Asperen, J.
van Tellingen, O.
Sparreboom, A.
Schinkel, A. H.
Borst, P.
Nooijen, W. J.
Beijnen, J. H.
author_facet van Asperen, J.
van Tellingen, O.
Sparreboom, A.
Schinkel, A. H.
Borst, P.
Nooijen, W. J.
Beijnen, J. H.
author_sort van Asperen, J.
collection PubMed
description Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel.
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spelling pubmed-22281332009-09-10 Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. van Asperen, J. van Tellingen, O. Sparreboom, A. Schinkel, A. H. Borst, P. Nooijen, W. J. Beijnen, J. H. Br J Cancer Research Article Inhibition of intestinal P-glycoprotein might enhance the absorption of orally administered P-glycoprotein substrate drugs. We show here a 10-fold increased oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833. These results encourage further research on the development of a clinically useful oral formulation of paclitaxel. Nature Publishing Group 1997 /pmc/articles/PMC2228133/ /pubmed/9365166 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
van Asperen, J.
van Tellingen, O.
Sparreboom, A.
Schinkel, A. H.
Borst, P.
Nooijen, W. J.
Beijnen, J. H.
Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title_full Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title_fullStr Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title_full_unstemmed Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title_short Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833.
title_sort enhanced oral bioavailability of paclitaxel in mice treated with the p-glycoprotein blocker sdz psc 833.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228133/
https://www.ncbi.nlm.nih.gov/pubmed/9365166
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