Kinetics of mouse jejunum radiosensitization by 2',2'-difluorodeoxycytidine (gemcitabine) and its relationship with pharmacodynamics of DNA synthesis inhibition and cell cycle redistribution in crypt cells.

Gemcitabine (dFdC), a deoxycitidine nucleoside analogue, inhibits DNA synthesis and repair of radiation-induced chromosome breaks in vitro, radiosensitizes various human and mouse cells in vitro and shows clinical activity in several tumours. Limited data are however available on the effect of dFdC...

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Detalles Bibliográficos
Autores principales: Grégoire, V., Beauduin, M., Rosier, J. F., De Coster, B., Bruniaux, M., Octave-Prignot, M., Scalliet, P.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228152/
https://www.ncbi.nlm.nih.gov/pubmed/9374377

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228152/
https://www.ncbi.nlm.nih.gov/pubmed/9374377

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