Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.

To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only wi...

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Autores principales: Bièche, I., Noguès, C., Rivoilan, S., Khodja, A., Latil, A., Lidereau, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228174/
https://www.ncbi.nlm.nih.gov/pubmed/9400936
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author Bièche, I.
Noguès, C.
Rivoilan, S.
Khodja, A.
Latil, A.
Lidereau, R.
author_facet Bièche, I.
Noguès, C.
Rivoilan, S.
Khodja, A.
Latil, A.
Lidereau, R.
author_sort Bièche, I.
collection PubMed
description To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer.
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spelling pubmed-22281742009-09-10 Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma. Bièche, I. Noguès, C. Rivoilan, S. Khodja, A. Latil, A. Lidereau, R. Br J Cancer Research Article To confirm several recent studies pointing to loss of heterozygosity (LOH) at BRCA2 as a prognostic factor in sporadic breast cancer, we examined this genetic alteration in a large series of human primary breast tumours for which long-term patient outcomes were known. LOH at BRCA2 correlated only with low oestrogen and progesterone receptor content. Univariate analysis of metastasis-free survival and overall survival (log-rank test) showed no link with BRCA2 status (P = 0.34, P = 0.29 respectively). LOH at BRCA2 does not therefore appear to be a major prognostic marker in sporadic breast cancer. Nature Publishing Group 1997 /pmc/articles/PMC2228174/ /pubmed/9400936 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Bièche, I.
Noguès, C.
Rivoilan, S.
Khodja, A.
Latil, A.
Lidereau, R.
Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title_full Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title_fullStr Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title_full_unstemmed Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title_short Prognostic value of loss of heterozygosity at BRCA2 in human breast carcinoma.
title_sort prognostic value of loss of heterozygosity at brca2 in human breast carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228174/
https://www.ncbi.nlm.nih.gov/pubmed/9400936
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