Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.

The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine l...

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Autores principales: Velikova, G., Banks, R. E., Gearing, A., Hemingway, I., Forbes, M. A., Preston, S. R., Jones, M., Wyatt, J., Miller, K., Ward, U., Al-Maskatti, J., Singh, S. M., Ambrose, N. S., Primrose, J. N., Selby, P. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228185/
https://www.ncbi.nlm.nih.gov/pubmed/9400933
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author Velikova, G.
Banks, R. E.
Gearing, A.
Hemingway, I.
Forbes, M. A.
Preston, S. R.
Jones, M.
Wyatt, J.
Miller, K.
Ward, U.
Al-Maskatti, J.
Singh, S. M.
Ambrose, N. S.
Primrose, J. N.
Selby, P. J.
author_facet Velikova, G.
Banks, R. E.
Gearing, A.
Hemingway, I.
Forbes, M. A.
Preston, S. R.
Jones, M.
Wyatt, J.
Miller, K.
Ward, U.
Al-Maskatti, J.
Singh, S. M.
Ambrose, N. S.
Primrose, J. N.
Selby, P. J.
author_sort Velikova, G.
collection PubMed
description The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P = 0.0361). IMAGES:
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spelling pubmed-22281852009-09-10 Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer. Velikova, G. Banks, R. E. Gearing, A. Hemingway, I. Forbes, M. A. Preston, S. R. Jones, M. Wyatt, J. Miller, K. Ward, U. Al-Maskatti, J. Singh, S. M. Ambrose, N. S. Primrose, J. N. Selby, P. J. Br J Cancer Research Article The concentrations of the soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) were investigated in 45 patients with gastric cancer before treatment and their correlation with clinical, histological and routine laboratory parameters was examined. Data were collected on tumour stage at presentation, presence and sites of metastatic disease, tumour pathology, survival and results of routine laboratory tests. Serum concentrations of ICAM-1 and VCAM-1 were significantly elevated in the patients with gastric cancer in comparison with the group of healthy subjects (P < 0.00001 and P < 0.0001 respectively). Increased serum concentrations of VCAM-1 were associated with locally advanced and metastatic disease whereas ICAM-1 was significantly elevated both in local and in advanced/metastatic disease. Soluble E-cadherin and E-selectin concentrations did not show any significant elevation in gastric cancer patients. Concentrations of soluble adhesion molecules showed significant correlation with each other (except E-selectin and VCAM-1) and with alkaline phosphatase. Soluble ICAM-1 and VCAM-1 were significantly associated with an elevated total white cell count. Patients with elevated VCAM-1 had significantly poorer survival in comparison with patients with normal serum levels (P = 0.0361). IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228185/ /pubmed/9400933 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Velikova, G.
Banks, R. E.
Gearing, A.
Hemingway, I.
Forbes, M. A.
Preston, S. R.
Jones, M.
Wyatt, J.
Miller, K.
Ward, U.
Al-Maskatti, J.
Singh, S. M.
Ambrose, N. S.
Primrose, J. N.
Selby, P. J.
Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title_full Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title_fullStr Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title_full_unstemmed Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title_short Circulating soluble adhesion molecules E-cadherin, E-selectin, intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in patients with gastric cancer.
title_sort circulating soluble adhesion molecules e-cadherin, e-selectin, intercellular adhesion molecule-1 (icam-1) and vascular cell adhesion molecule-1 (vcam-1) in patients with gastric cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228185/
https://www.ncbi.nlm.nih.gov/pubmed/9400933
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