Thrombin has a bimodal effect on glioma cell growth.

Using rat glioma C6 cells as a model, we have found a bimodal effect of alpha-thrombin on cell growth. In C6 cells treated with alpha-thrombin at concentrations from 0.02 nM to 1.0 nM, inhibition of cell proliferation was noted. Because the thrombin receptor agonist peptide TRAP-6 also induced inhib...

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Detalles Bibliográficos
Autores principales: Schafberg, H., Nowak, G., Kaufmann, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228214/
https://www.ncbi.nlm.nih.gov/pubmed/9413947
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author Schafberg, H.
Nowak, G.
Kaufmann, R.
author_facet Schafberg, H.
Nowak, G.
Kaufmann, R.
author_sort Schafberg, H.
collection PubMed
description Using rat glioma C6 cells as a model, we have found a bimodal effect of alpha-thrombin on cell growth. In C6 cells treated with alpha-thrombin at concentrations from 0.02 nM to 1.0 nM, inhibition of cell proliferation was noted. Because the thrombin receptor agonist peptide TRAP-6 also induced inhibition of cell proliferation and the thrombin receptor antagonist peptide T1 prevented the inhibitory effect of alpha-thrombin on C6 glioma cell growth, thrombin receptor involvement in antiproliferative action of alpha-thrombin in C6 glioma cells is highly likely. However, stimulation of cell proliferation observed when C6 cells were treated with alpha-thrombin at higher doses (> 1.0 nM) seems to be mediated by as yet undefined thrombin receptor-independent biochemical mechanisms.
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spelling pubmed-22282142009-09-10 Thrombin has a bimodal effect on glioma cell growth. Schafberg, H. Nowak, G. Kaufmann, R. Br J Cancer Research Article Using rat glioma C6 cells as a model, we have found a bimodal effect of alpha-thrombin on cell growth. In C6 cells treated with alpha-thrombin at concentrations from 0.02 nM to 1.0 nM, inhibition of cell proliferation was noted. Because the thrombin receptor agonist peptide TRAP-6 also induced inhibition of cell proliferation and the thrombin receptor antagonist peptide T1 prevented the inhibitory effect of alpha-thrombin on C6 glioma cell growth, thrombin receptor involvement in antiproliferative action of alpha-thrombin in C6 glioma cells is highly likely. However, stimulation of cell proliferation observed when C6 cells were treated with alpha-thrombin at higher doses (> 1.0 nM) seems to be mediated by as yet undefined thrombin receptor-independent biochemical mechanisms. Nature Publishing Group 1997 /pmc/articles/PMC2228214/ /pubmed/9413947 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Schafberg, H.
Nowak, G.
Kaufmann, R.
Thrombin has a bimodal effect on glioma cell growth.
title Thrombin has a bimodal effect on glioma cell growth.
title_full Thrombin has a bimodal effect on glioma cell growth.
title_fullStr Thrombin has a bimodal effect on glioma cell growth.
title_full_unstemmed Thrombin has a bimodal effect on glioma cell growth.
title_short Thrombin has a bimodal effect on glioma cell growth.
title_sort thrombin has a bimodal effect on glioma cell growth.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228214/
https://www.ncbi.nlm.nih.gov/pubmed/9413947
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AT nowakg thrombinhasabimodaleffectongliomacellgrowth
AT kaufmannr thrombinhasabimodaleffectongliomacellgrowth

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