Infrequent microsatellite instability in oesophageal cancers.

Alterations of microsatellites have been found at relatively high frequency in hereditary and sporadic colorectal cancer and gastric and pancreatic cancers and at lower frequency in some other cancers. We determined the frequency of instability at 39 poly-CA microsatellite loci in 20 squamous cell c...

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Autores principales: Muzeau, F., Fléjou, J. F., Belghiti, J., Thomas, G., Hamelin, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1997
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228236/
https://www.ncbi.nlm.nih.gov/pubmed/9155055
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author Muzeau, F.
Fléjou, J. F.
Belghiti, J.
Thomas, G.
Hamelin, R.
author_facet Muzeau, F.
Fléjou, J. F.
Belghiti, J.
Thomas, G.
Hamelin, R.
author_sort Muzeau, F.
collection PubMed
description Alterations of microsatellites have been found at relatively high frequency in hereditary and sporadic colorectal cancer and gastric and pancreatic cancers and at lower frequency in some other cancers. We determined the frequency of instability at 39 poly-CA microsatellite loci in 20 squamous cell carcinomas and 26 Barrett's adenocarcinomas of the oesophagus. None of the tumours presented instability for a high percentage of the tested loci. Four squamous cell carcinomas and six Barrett's adenocarcinomas showed microsatellite instability at one locus, and three Barrett's adenocarcinomas showed microsatellite instability at two loci. The presence of few loci showing microsatellite instability could be due to an instability background. We conclude that genetic defects in the DNA mismatch repair system do not play an important role in oesophageal cancers. IMAGES:
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spelling pubmed-22282362009-09-10 Infrequent microsatellite instability in oesophageal cancers. Muzeau, F. Fléjou, J. F. Belghiti, J. Thomas, G. Hamelin, R. Br J Cancer Research Article Alterations of microsatellites have been found at relatively high frequency in hereditary and sporadic colorectal cancer and gastric and pancreatic cancers and at lower frequency in some other cancers. We determined the frequency of instability at 39 poly-CA microsatellite loci in 20 squamous cell carcinomas and 26 Barrett's adenocarcinomas of the oesophagus. None of the tumours presented instability for a high percentage of the tested loci. Four squamous cell carcinomas and six Barrett's adenocarcinomas showed microsatellite instability at one locus, and three Barrett's adenocarcinomas showed microsatellite instability at two loci. The presence of few loci showing microsatellite instability could be due to an instability background. We conclude that genetic defects in the DNA mismatch repair system do not play an important role in oesophageal cancers. IMAGES: Nature Publishing Group 1997 /pmc/articles/PMC2228236/ /pubmed/9155055 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Muzeau, F.
Fléjou, J. F.
Belghiti, J.
Thomas, G.
Hamelin, R.
Infrequent microsatellite instability in oesophageal cancers.
title Infrequent microsatellite instability in oesophageal cancers.
title_full Infrequent microsatellite instability in oesophageal cancers.
title_fullStr Infrequent microsatellite instability in oesophageal cancers.
title_full_unstemmed Infrequent microsatellite instability in oesophageal cancers.
title_short Infrequent microsatellite instability in oesophageal cancers.
title_sort infrequent microsatellite instability in oesophageal cancers.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228236/
https://www.ncbi.nlm.nih.gov/pubmed/9155055
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AT hamelinr infrequentmicrosatelliteinstabilityinoesophagealcancers

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