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Towards reconciling structure and function in the nuclear pore complex
The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope. Being the only passageway in and out of the nucleus, the nuclear pore complex (NPC) has the principal function of regulating th...
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Springer-Verlag
2008
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228380/ https://www.ncbi.nlm.nih.gov/pubmed/18228033 http://dx.doi.org/10.1007/s00418-007-0371-x |
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author | Lim, Roderick Y. H. Aebi, Ueli Fahrenkrog, Birthe |
author_facet | Lim, Roderick Y. H. Aebi, Ueli Fahrenkrog, Birthe |
author_sort | Lim, Roderick Y. H. |
collection | PubMed |
description | The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope. Being the only passageway in and out of the nucleus, the nuclear pore complex (NPC) has the principal function of regulating the high throughput of nucleocytoplasmic transport in a highly selective manner so as to maintain cellular order and function. Here, we present a retrospective review of the evidence that has led to the current understanding of both NPC structure and function. Looking towards the future, we contemplate on how various outstanding effects and nanoscopic characteristics ought to be addressed, with the goal of reconciling structure and function into a single unified picture of the NPC. |
format | Text |
id | pubmed-2228380 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2008 |
publisher | Springer-Verlag |
record_format | MEDLINE/PubMed |
spelling | pubmed-22283802008-02-05 Towards reconciling structure and function in the nuclear pore complex Lim, Roderick Y. H. Aebi, Ueli Fahrenkrog, Birthe Histochem Cell Biol Review The spatial separation between the cytoplasm and the cell nucleus necessitates the continuous exchange of macromolecular cargo across the double-membraned nuclear envelope. Being the only passageway in and out of the nucleus, the nuclear pore complex (NPC) has the principal function of regulating the high throughput of nucleocytoplasmic transport in a highly selective manner so as to maintain cellular order and function. Here, we present a retrospective review of the evidence that has led to the current understanding of both NPC structure and function. Looking towards the future, we contemplate on how various outstanding effects and nanoscopic characteristics ought to be addressed, with the goal of reconciling structure and function into a single unified picture of the NPC. Springer-Verlag 2008-01-29 2008-02 /pmc/articles/PMC2228380/ /pubmed/18228033 http://dx.doi.org/10.1007/s00418-007-0371-x Text en © Springer-Verlag 2008 |
spellingShingle | Review Lim, Roderick Y. H. Aebi, Ueli Fahrenkrog, Birthe Towards reconciling structure and function in the nuclear pore complex |
title | Towards reconciling structure and function in the nuclear pore complex |
title_full | Towards reconciling structure and function in the nuclear pore complex |
title_fullStr | Towards reconciling structure and function in the nuclear pore complex |
title_full_unstemmed | Towards reconciling structure and function in the nuclear pore complex |
title_short | Towards reconciling structure and function in the nuclear pore complex |
title_sort | towards reconciling structure and function in the nuclear pore complex |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228380/ https://www.ncbi.nlm.nih.gov/pubmed/18228033 http://dx.doi.org/10.1007/s00418-007-0371-x |
work_keys_str_mv | AT limroderickyh towardsreconcilingstructureandfunctioninthenuclearporecomplex AT aebiueli towardsreconcilingstructureandfunctioninthenuclearporecomplex AT fahrenkrogbirthe towardsreconcilingstructureandfunctioninthenuclearporecomplex |