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Permeability of the sodium channel in Myxicola to organic cations

The relative permeability of sodium channels to organic cations was determined in the Myxicola giant axon. Ionic currents under potential control were measured in seawater and in sodium-free solutions containing the organic cation. The measured reversal potential and the Goldman equation were used t...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1976
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228445/
https://www.ncbi.nlm.nih.gov/pubmed/993772
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description The relative permeability of sodium channels to organic cations was determined in the Myxicola giant axon. Ionic currents under potential control were measured in seawater and in sodium-free solutions containing the organic cation. The measured reversal potential and the Goldman equation were used to obtain the relative permeabilities. The permeability sequence was found to be: sodium greater than hydroxylamine greater than hydrazine greater than ammonium greater than guanidine greater than formamidine greater than aminoguanidine greater than methylamine. Measurements were also made on sodium and several of the organic cations at different concentrations. The relative permeabilities of the ions were found to be independent of concentration. Qualitatively, the permeability sequence for the Myxicola giant axon was similar to that of the frog node of Ranvier.
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spelling pubmed-22284452008-04-23 Permeability of the sodium channel in Myxicola to organic cations J Gen Physiol Articles The relative permeability of sodium channels to organic cations was determined in the Myxicola giant axon. Ionic currents under potential control were measured in seawater and in sodium-free solutions containing the organic cation. The measured reversal potential and the Goldman equation were used to obtain the relative permeabilities. The permeability sequence was found to be: sodium greater than hydroxylamine greater than hydrazine greater than ammonium greater than guanidine greater than formamidine greater than aminoguanidine greater than methylamine. Measurements were also made on sodium and several of the organic cations at different concentrations. The relative permeabilities of the ions were found to be independent of concentration. Qualitatively, the permeability sequence for the Myxicola giant axon was similar to that of the frog node of Ranvier. The Rockefeller University Press 1976-11-01 /pmc/articles/PMC2228445/ /pubmed/993772 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Permeability of the sodium channel in Myxicola to organic cations
title Permeability of the sodium channel in Myxicola to organic cations
title_full Permeability of the sodium channel in Myxicola to organic cations
title_fullStr Permeability of the sodium channel in Myxicola to organic cations
title_full_unstemmed Permeability of the sodium channel in Myxicola to organic cations
title_short Permeability of the sodium channel in Myxicola to organic cations
title_sort permeability of the sodium channel in myxicola to organic cations
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228445/
https://www.ncbi.nlm.nih.gov/pubmed/993772