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The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina

The effect of intravenous strychnine and the GABA antagonists picrotoxin and bicuculline upon the discharge pattern of center- surround-organized cat retinal ganglion cells of X and Y type were studied. Stimuli (mostly scotopic, and some photopic) were selected such that responses from both on and o...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1979
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228482/
https://www.ncbi.nlm.nih.gov/pubmed/479822
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description The effect of intravenous strychnine and the GABA antagonists picrotoxin and bicuculline upon the discharge pattern of center- surround-organized cat retinal ganglion cells of X and Y type were studied. Stimuli (mostly scotopic, and some photopic) were selected such that responses from both on and off-center cells were either due to the center, due to the surround, or clearly mixed. Pre-drug control responses were obtained, and their behavior following administration of the antagonists was observed for periods up to several hours. X-cell responses were affected in a consistent manner by strychnine while being unaffected by GABA antagonists. All observed changes following strychnine were consistent with a shift in center-surround balance of X cells in favor of the center. For Y-cell responses to flashing annuli following strychnine, there was either no shift or a relatively small shift in center-surround balance. Compared to X-cell responses to flashing lights, those of Y cells were very little affected by strychnine and in most cases were unaffected. It thus appears that glycine plays a similar role in receptive field organization of X cells as does GABA in Y cells (Kirby and Enroth-Cugell, 1976. J. Gen. Physiol. 68:465-484).
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spelling pubmed-22284822008-04-23 The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina J Gen Physiol Articles The effect of intravenous strychnine and the GABA antagonists picrotoxin and bicuculline upon the discharge pattern of center- surround-organized cat retinal ganglion cells of X and Y type were studied. Stimuli (mostly scotopic, and some photopic) were selected such that responses from both on and off-center cells were either due to the center, due to the surround, or clearly mixed. Pre-drug control responses were obtained, and their behavior following administration of the antagonists was observed for periods up to several hours. X-cell responses were affected in a consistent manner by strychnine while being unaffected by GABA antagonists. All observed changes following strychnine were consistent with a shift in center-surround balance of X cells in favor of the center. For Y-cell responses to flashing annuli following strychnine, there was either no shift or a relatively small shift in center-surround balance. Compared to X-cell responses to flashing lights, those of Y cells were very little affected by strychnine and in most cases were unaffected. It thus appears that glycine plays a similar role in receptive field organization of X cells as does GABA in Y cells (Kirby and Enroth-Cugell, 1976. J. Gen. Physiol. 68:465-484). The Rockefeller University Press 1979-07-01 /pmc/articles/PMC2228482/ /pubmed/479822 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title_full The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title_fullStr The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title_full_unstemmed The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title_short The effect of strychnine, bicuculline, and picrotoxin on X and Y cells in the cat retina
title_sort effect of strychnine, bicuculline, and picrotoxin on x and y cells in the cat retina
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228482/
https://www.ncbi.nlm.nih.gov/pubmed/479822