Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance

The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage- dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predic...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1982
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228681/
https://www.ncbi.nlm.nih.gov/pubmed/6292331
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collection PubMed
description The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage- dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels.
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spelling pubmed-22286812008-04-23 Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance J Gen Physiol Articles The voltage dependence of the conductance induced induced in thin lipid membranes by monazomycin is shown here to be caused by voltage- dependent variations in the frequency of channel openings. We also experimentally demonstrate certain interesting properties of the channel activity that are predicted by a chemical kinetic model (Muller and Peskin, 1981), which successfully describes the macroscopic conductance. We conclude that two parallel mechanisms--one autocatalytic, the other simple mass action--exist that allow monazomycin to enter (or leave) the membrane so that the monazomycin molecules can be in a position to form channels. The Rockefeller University Press 1982-09-01 /pmc/articles/PMC2228681/ /pubmed/6292331 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title_full Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title_fullStr Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title_full_unstemmed Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title_short Monazomycin-induced single channels. II. Origin of the voltage dependence of the macroscopic conductance
title_sort monazomycin-induced single channels. ii. origin of the voltage dependence of the macroscopic conductance
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2228681/
https://www.ncbi.nlm.nih.gov/pubmed/6292331

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