Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition

Hypertonic shrinkage of dog red cells caused rapid activation of Na/H exchange and rapid deactivation of [K-Cl] cotransport. Hypotonic swelling caused delayed deactivation of Na/H exchange and delayed activation of [K-Cl] cotransport. Okadaic acid stimulated shrinkage- induced Na/H exchange and inhi...

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Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1991
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Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229096/
https://www.ncbi.nlm.nih.gov/pubmed/1662683
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collection PubMed
description Hypertonic shrinkage of dog red cells caused rapid activation of Na/H exchange and rapid deactivation of [K-Cl] cotransport. Hypotonic swelling caused delayed deactivation of Na/H exchange and delayed activation of [K-Cl] cotransport. Okadaic acid stimulated shrinkage- induced Na/H exchange and inhibited swelling-induced [K-Cl] cotransport. The data are compatible with the kinetic model of Jennings and Al-Rohil (1990. J. Gen. Physiol. 95:1021-1040) for volume regulation of [K-Cl] cotransport in rabbit red cells and suggest that in dog red cells Na/H exchange and [K-Cl] cotransport are controlled by a common regulatory system. The proposal of Jennings and Schulz (1991. J. Gen. Physiol. 96:799-817) that activation/deactivation of volume- sensitive transport involves phosphorylation/dephosphorylation of a regulatory protein is supported by these observations.
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spelling pubmed-22290962008-04-23 Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition J Gen Physiol Articles Hypertonic shrinkage of dog red cells caused rapid activation of Na/H exchange and rapid deactivation of [K-Cl] cotransport. Hypotonic swelling caused delayed deactivation of Na/H exchange and delayed activation of [K-Cl] cotransport. Okadaic acid stimulated shrinkage- induced Na/H exchange and inhibited swelling-induced [K-Cl] cotransport. The data are compatible with the kinetic model of Jennings and Al-Rohil (1990. J. Gen. Physiol. 95:1021-1040) for volume regulation of [K-Cl] cotransport in rabbit red cells and suggest that in dog red cells Na/H exchange and [K-Cl] cotransport are controlled by a common regulatory system. The proposal of Jennings and Schulz (1991. J. Gen. Physiol. 96:799-817) that activation/deactivation of volume- sensitive transport involves phosphorylation/dephosphorylation of a regulatory protein is supported by these observations. The Rockefeller University Press 1991-11-01 /pmc/articles/PMC2229096/ /pubmed/1662683 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).
spellingShingle Articles
Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title_full Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title_fullStr Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title_full_unstemmed Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title_short Coordinated regulation of shrinkage-induced Na/H exchange and swelling- induced [K-Cl] cotransport in dog red cells. Further evidence from activation kinetics and phosphatase inhibition
title_sort coordinated regulation of shrinkage-induced na/h exchange and swelling- induced [k-cl] cotransport in dog red cells. further evidence from activation kinetics and phosphatase inhibition
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229096/
https://www.ncbi.nlm.nih.gov/pubmed/1662683

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