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P-loop Flexibility in Na(+) Channel Pores Revealed by Single- and Double-cysteine Replacements

Replacement of individual P-loop residues with cysteines in rat skeletal muscle Na(+) channels (SkM1) caused an increased sensitivity to current blockade by Cd(2+) thus allowing detection of residues lining the pore. Simultaneous replacement of two residues in distinct P-loops created channels with...

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Detalles Bibliográficos
Autores principales:	Tsushima, Robert G., Li, Ronald A., Backx, Peter H.
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1997
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229360/ https://www.ncbi.nlm.nih.gov/pubmed/9234171

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