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Block of the Kir2.1 Channel Pore by Alkylamine Analogues of Endogenous Polyamines
Inward rectification induced by mono- and diaminoalkane application to inside-out membrane patches was studied in Kir2.1 (IRK1) channels expressed in Xenopus oocytes. Both monoamines and diamines block Kir2.1 channels, with potency increasing as the alkyl chain length increases (from 2 to 12 methyle...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1998
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229415/ https://www.ncbi.nlm.nih.gov/pubmed/9725894 |