A Structural Rearrangement in the Sodium Channel Pore Linked to Slow Inactivation and Use Dependence

Voltage-gated sodium (Na(+)) channels are a fundamental target for modulating excitability in neuronal and muscle cells. When depolarized, Na(+) channels may gradually enter long-lived, slow-inactivated conformational states, causing a cumulative loss of function. Although the structural motifs that...

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Detalles Bibliográficos
Autores principales: Ong, Boon-Hooi, Tomaselli, Gordon F., Balser, Jeffrey R.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229478/
https://www.ncbi.nlm.nih.gov/pubmed/11055994

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229478/
https://www.ncbi.nlm.nih.gov/pubmed/11055994

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