Structural Determinants of Pip(2) Regulation of Inward Rectifier K(ATP) Channels

Phosphatidylinositol 4,5-bisphosphate (PIP(2)) activates K(ATP) and other inward rectifier (Kir) channels. To determine residues important for PIP(2) regulation, we have systematically mutated each positive charge in the COOH terminus of Kir6.2 to alanine. The effects of these mutations on channel f...

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Detalles Bibliográficos
Autores principales: Shyng, Show-Ling, Cukras, Catherine A., Harwood, Jane, Nichols, Colin G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2000
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229479/
https://www.ncbi.nlm.nih.gov/pubmed/11055989

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