Stabilization of the Activity of ATP-sensitive Potassium Channels by Ion Pairs Formed between Adjacent Kir6.2 Subunits

ATP-sensitive potassium (K(ATP)) channels are formed by the coassembly of four Kir6.2 subunits and four sulfonylurea receptor subunits (SUR). The cytoplasmic domains of Kir6.2 mediate channel gating by ATP, which closes the channel, and membrane phosphoinositides, which stabilize the open channel. L...

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Detalles Bibliográficos
Autores principales: Lin, Yu-Wen, Jia, Taiping, Weinsoft, Anne M., Shyng, Show-Ling
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2003
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229541/
https://www.ncbi.nlm.nih.gov/pubmed/12885877
http://dx.doi.org/10.1085/jgp.200308822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229541/
https://www.ncbi.nlm.nih.gov/pubmed/12885877
http://dx.doi.org/10.1085/jgp.200308822

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