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Ser165 in the Second Transmembrane Region of the Kir2.1 Channel Determines its Susceptibility to Blockade by Intracellular Mg(2+)
The strong inward rectification of Kir2.1 currents is reportedly due to blockade of the outward current by cytoplasmic magnesium (Mg(2+) (i)) and polyamines, and is known to be determined in part by three negatively charged amino acid residues: Asp172, Glu224, and Glu299 (D172, E224, E299). Our aim...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
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The Rockefeller University Press
2002
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229556/ https://www.ncbi.nlm.nih.gov/pubmed/12407079 http://dx.doi.org/10.1085/jgp.20028663 |