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Spontaneous Channel Activity of the Inositol 1,4,5-Trisphosphate (InsP(3)) Receptor (InsP(3)R). Application of Allosteric Modeling to Calcium and InsP(3) Regulation of InsP(3)R Single-channel Gating

The InsP(3)R Ca(2+) release channel has a biphasic dependence on cytoplasmic free Ca(2+) concentration ([Ca(2+)](i)). InsP(3) activates gating primarily by reducing the sensitivity of the channel to inhibition by high [Ca(2+)](i). To determine if relieving Ca(2+) inhibition is sufficient for channel...

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Detalles Bibliográficos
Autores principales:	Mak, Don-On Daniel, McBride, Sean M.J., Foskett, J. Kevin
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2003
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229577/ https://www.ncbi.nlm.nih.gov/pubmed/14581584 http://dx.doi.org/10.1085/jgp.200308809

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