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Gating Kinetics of Single Large-Conductance Ca(2+)-Activated K(+) Channels in High Ca(2+) Suggest a Two-Tiered Allosteric Gating Mechanism(✪)
The Ca(2+)-dependent gating mechanism of large-conductance calcium-activated K(+) (BK) channels from cultured rat skeletal muscle was examined from low (4 μM) to high (1,024 μM) intracellular concentrations of calcium (Ca(2+) (i)) using single-channel recording. Open probability (P (o)) increased wi...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
1999
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229641/ https://www.ncbi.nlm.nih.gov/pubmed/10398695 |