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The Block of Shaker K(+) Channels by κ-Conotoxin Pviia Is State Dependent

κ-conotoxin PVIIA is the first conotoxin known to interact with voltage-gated potassium channels by inhibiting Shaker-mediated currents. We studied the mechanism of inhibition and concluded that PVIIA blocks the ion pore with a 1:1 stoichiometry and that binding to open or closed channels is very di...

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Detalles Bibliográficos
Autores principales:	Terlau, Heinrich, Boccaccio, Anna, Olivera, Baldomero M., Conti, Franco
Formato:	Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 1999
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229645/ https://www.ncbi.nlm.nih.gov/pubmed/10398696

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