The ER-Bound RING Finger Protein 5 (RNF5/RMA1) Causes Degenerative Myopathy in Transgenic Mice and Is Deregulated in Inclusion Body Myositis

Growing evidence supports the importance of ubiquitin ligases in the pathogenesis of muscular disorders, although underlying mechanisms remain largely elusive. Here we show that the expression of RNF5 (aka RMA1), an ER-anchored RING finger E3 ligase implicated in muscle organization and in recogniti...

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Detalles Bibliográficos
Autores principales: Delaunay, Agnès, Bromberg, Kenneth D., Hayashi, Yukiko, Mirabella, Massimiliano, Burch, Denise, Kirkwood, Brian, Serra, Carlo, Malicdan, May C., Mizisin, Andrew P., Morosetti, Roberta, Broccolini, Aldobrando, Guo, Ling T., Jones, Stephen N., Lira, Sergio A., Puri, Pier Lorenzo, Shelton, G. Diane, Ronai, Ze'ev
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229664/
https://www.ncbi.nlm.nih.gov/pubmed/18270596
http://dx.doi.org/10.1371/journal.pone.0001609

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