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Electron Microscope Observations of the Melanocyte of the Human Epidermis

Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cel...

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Detalles Bibliográficos
Autores principales: Charles, Arwyn, Ingram, John T.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1959
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229755/
https://www.ncbi.nlm.nih.gov/pubmed/13673044
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author Charles, Arwyn
Ingram, John T.
author_facet Charles, Arwyn
Ingram, John T.
author_sort Charles, Arwyn
collection PubMed
description Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cells. The passage of melanin from melanocyte to Malpighian cell—cytocrine secretion—is thought to have been observed. Phagocytes near the dermal-epidermal junction seem to have their pigment granules in vacuoles, rather than surrounded directly by the cytoplasmic matrix as in the melanocytes. This, together with the failure to observe "effete" melanocytes, prompts the suggestion that the phagocytes are melanocytes which have migrated from the epidermis into the dermis. A melanin granule is shown with alternating dark and lighter transverse striations, concerning which structure little can at present be said.
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spelling pubmed-22297552008-05-01 Electron Microscope Observations of the Melanocyte of the Human Epidermis Charles, Arwyn Ingram, John T. J Biophys Biochem Cytol Article Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cells. The passage of melanin from melanocyte to Malpighian cell—cytocrine secretion—is thought to have been observed. Phagocytes near the dermal-epidermal junction seem to have their pigment granules in vacuoles, rather than surrounded directly by the cytoplasmic matrix as in the melanocytes. This, together with the failure to observe "effete" melanocytes, prompts the suggestion that the phagocytes are melanocytes which have migrated from the epidermis into the dermis. A melanin granule is shown with alternating dark and lighter transverse striations, concerning which structure little can at present be said. The Rockefeller University Press 1959-08-01 /pmc/articles/PMC2229755/ /pubmed/13673044 Text en Copyright © Copyright, 1959, by The Rockefeller Institute
spellingShingle Article
Charles, Arwyn
Ingram, John T.
Electron Microscope Observations of the Melanocyte of the Human Epidermis
title Electron Microscope Observations of the Melanocyte of the Human Epidermis
title_full Electron Microscope Observations of the Melanocyte of the Human Epidermis
title_fullStr Electron Microscope Observations of the Melanocyte of the Human Epidermis
title_full_unstemmed Electron Microscope Observations of the Melanocyte of the Human Epidermis
title_short Electron Microscope Observations of the Melanocyte of the Human Epidermis
title_sort electron microscope observations of the melanocyte of the human epidermis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229755/
https://www.ncbi.nlm.nih.gov/pubmed/13673044
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