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Electron Microscope Observations of the Melanocyte of the Human Epidermis
Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cel...
Autores principales: | , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
1959
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229755/ https://www.ncbi.nlm.nih.gov/pubmed/13673044 |
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author | Charles, Arwyn Ingram, John T. |
author_facet | Charles, Arwyn Ingram, John T. |
author_sort | Charles, Arwyn |
collection | PubMed |
description | Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cells. The passage of melanin from melanocyte to Malpighian cell—cytocrine secretion—is thought to have been observed. Phagocytes near the dermal-epidermal junction seem to have their pigment granules in vacuoles, rather than surrounded directly by the cytoplasmic matrix as in the melanocytes. This, together with the failure to observe "effete" melanocytes, prompts the suggestion that the phagocytes are melanocytes which have migrated from the epidermis into the dermis. A melanin granule is shown with alternating dark and lighter transverse striations, concerning which structure little can at present be said. |
format | Text |
id | pubmed-2229755 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1959 |
publisher | The Rockefeller University Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-22297552008-05-01 Electron Microscope Observations of the Melanocyte of the Human Epidermis Charles, Arwyn Ingram, John T. J Biophys Biochem Cytol Article Using standard osmium fixation and methacrylate embedding techniques, a study has been made of the melanocyte of human biopsy skin removed under general and local anaesthesia. Melanogenesis was easily observable in the melanocytes, but immature pigment granules were rarely seen in the Malpighian cells. The passage of melanin from melanocyte to Malpighian cell—cytocrine secretion—is thought to have been observed. Phagocytes near the dermal-epidermal junction seem to have their pigment granules in vacuoles, rather than surrounded directly by the cytoplasmic matrix as in the melanocytes. This, together with the failure to observe "effete" melanocytes, prompts the suggestion that the phagocytes are melanocytes which have migrated from the epidermis into the dermis. A melanin granule is shown with alternating dark and lighter transverse striations, concerning which structure little can at present be said. The Rockefeller University Press 1959-08-01 /pmc/articles/PMC2229755/ /pubmed/13673044 Text en Copyright © Copyright, 1959, by The Rockefeller Institute |
spellingShingle | Article Charles, Arwyn Ingram, John T. Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title | Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title_full | Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title_fullStr | Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title_full_unstemmed | Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title_short | Electron Microscope Observations of the Melanocyte of the Human Epidermis |
title_sort | electron microscope observations of the melanocyte of the human epidermis |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229755/ https://www.ncbi.nlm.nih.gov/pubmed/13673044 |
work_keys_str_mv | AT charlesarwyn electronmicroscopeobservationsofthemelanocyteofthehumanepidermis AT ingramjohnt electronmicroscopeobservationsofthemelanocyteofthehumanepidermis |