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An atypical orthologue of 6-pyruvoyltetrahydropterin synthase can provide the missing link in the folate biosynthesis pathway of malaria parasites

Folate metabolism in malaria parasites is a long-standing, clinical target for chemotherapy and prophylaxis. However, despite determination of the complete genome sequence of the lethal species Plasmodium falciparum, the pathway of de novo folate biosynthesis remains incomplete, as no candidate gene...

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Detalles Bibliográficos
Autores principales: Dittrich, Sabine, Mitchell, Sarah L, Blagborough, Andrew M, Wang, Qi, Wang, Ping, Sims, Paul F G, Hyde, John E
Formato: Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2008
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2229834/
https://www.ncbi.nlm.nih.gov/pubmed/18093090
http://dx.doi.org/10.1111/j.1365-2958.2007.06073.x