Sulfonylurea and K(+)-Channel Opener Sensitivity of K(ATP) Channels: Functional Coupling of Kir6.2 and Sur1 Subunits

The sensitivity of K(ATP) channels to high-affinity block by sulfonylureas and to stimulation by K(+) channel openers and MgADP (PCOs) is conferred by the regulatory sulfonylurea receptor (SUR) subunit, whereas ATP inhibits the channel through interaction with the inward rectifier (Kir6.2) subunit....

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Detalles Bibliográficos
Autores principales: Koster, J.C., Sha, Q., Nichols, C.G.
Formato: Texto
Lenguaje:English
Publicado: The Rockefeller University Press 1999
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2230640/
https://www.ncbi.nlm.nih.gov/pubmed/10435998

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