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Interaction of Scorpion α-Toxins with Cardiac Sodium Channels: Binding Properties and Enhancement of Slow Inactivation
The effects of the scorpion α-toxins Lqh II, Lqh III, and LqhαIT on human cardiac sodium channels (hH1), which were expressed in human embryonic kidney (HEK) 293 cells, were investigated. The toxins removed fast inactivation with EC (50) values of <2.5 nM (Lqh III), 12 nM (Lqh II), and 33 nM (Lqh...
| Autores principales: | , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
The Rockefeller University Press
2001
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2232402/ https://www.ncbi.nlm.nih.gov/pubmed/11382802 |