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Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis
BACKGROUND: The purpose of this study was to confirm that women with latent toxoplasmosis have developmentally younger fetuses at estimated pregnancy week 16 and to test four exclusive hypotheses that could explain the observed data. METHODS: In the present retrospective cohort study we analysed by...
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Formato: | Texto |
Lenguaje: | English |
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BioMed Central
2007
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233629/ https://www.ncbi.nlm.nih.gov/pubmed/17916246 http://dx.doi.org/10.1186/1471-2334-7-114 |
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author | Kaňková, Šárka Flegr, Jaroslav |
author_facet | Kaňková, Šárka Flegr, Jaroslav |
author_sort | Kaňková, Šárka |
collection | PubMed |
description | BACKGROUND: The purpose of this study was to confirm that women with latent toxoplasmosis have developmentally younger fetuses at estimated pregnancy week 16 and to test four exclusive hypotheses that could explain the observed data. METHODS: In the present retrospective cohort study we analysed by the GLM (general linear model) method data from 730 Toxoplasma-free and 185 Toxoplasma-infected pregnant women. RESULTS: At pregnancy week 16 estimated from the date of the last menstruation, the mothers with latent toxoplasmosis had developmentally younger fetuses based on ultrasound scan (P = 0.014). Pregnancy of Toxoplasma-positive compared to Toxoplasma-negative women was by about 1.3 days longer, as estimated both from the date of the last menstruation (P = 0.015) and by ultrasonography (P = 0.025). CONCLUSION: The most parsimonious explanation for the observed data is retarded fetal growth during the first weeks of pregnancy in Toxoplasma-positive women. The phenomenon was only detectable in multiparous women, suggesting that the immune system may play some role in it. |
format | Text |
id | pubmed-2233629 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-22336292008-02-07 Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis Kaňková, Šárka Flegr, Jaroslav BMC Infect Dis Research Article BACKGROUND: The purpose of this study was to confirm that women with latent toxoplasmosis have developmentally younger fetuses at estimated pregnancy week 16 and to test four exclusive hypotheses that could explain the observed data. METHODS: In the present retrospective cohort study we analysed by the GLM (general linear model) method data from 730 Toxoplasma-free and 185 Toxoplasma-infected pregnant women. RESULTS: At pregnancy week 16 estimated from the date of the last menstruation, the mothers with latent toxoplasmosis had developmentally younger fetuses based on ultrasound scan (P = 0.014). Pregnancy of Toxoplasma-positive compared to Toxoplasma-negative women was by about 1.3 days longer, as estimated both from the date of the last menstruation (P = 0.015) and by ultrasonography (P = 0.025). CONCLUSION: The most parsimonious explanation for the observed data is retarded fetal growth during the first weeks of pregnancy in Toxoplasma-positive women. The phenomenon was only detectable in multiparous women, suggesting that the immune system may play some role in it. BioMed Central 2007-10-04 /pmc/articles/PMC2233629/ /pubmed/17916246 http://dx.doi.org/10.1186/1471-2334-7-114 Text en Copyright © 2007 Kaňková and Flegr.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Kaňková, Šárka Flegr, Jaroslav Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title | Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title_full | Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title_fullStr | Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title_full_unstemmed | Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title_short | Longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
title_sort | longer pregnancy and slower fetal development in women with latent "asymptomatic" toxoplasmosis |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233629/ https://www.ncbi.nlm.nih.gov/pubmed/17916246 http://dx.doi.org/10.1186/1471-2334-7-114 |
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