Tissue factor pathway inhibitor-2 was repressed by CpG hypermethylation through inhibition of KLF6 binding in highly invasive breast cancer cells

BACKGROUND: Tissue factor pathway inhibitor-2 (TFPI-2) is a matrix-associated Kunitz inhibitor that inhibits plasmin and trypsin-mediated activation of zymogen matrix metalloproteinases involved in tumor progression, invasion and metastasis. Here, we have investigated the mechanism of DNA methylatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Guo, Hongshen, Lin, Yifeng, Zhang, Hongwei, Liu, Juan, Zhang, Nong, Li, Yiming, Kong, Desheng, Tang, Qiqun, Ma, Duan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233638/
https://www.ncbi.nlm.nih.gov/pubmed/18053161
http://dx.doi.org/10.1186/1471-2199-8-110

Ejemplares similares

Ejemplares similares