X Chromosome Activity in Mouse XX Primordial Germ Cells

In the early epiblast of female mice, one of the two X chromosomes is randomly inactivated by a Xist-dependent mechanism, involving the recruitment of Ezh2-Eed and the subsequent trimethylation of histone 3 on lysine 27 (H3K27me3). We demonstrate that this random inactivation process applies also to...

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Detalles Bibliográficos
Autores principales: Chuva de Sousa Lopes, Susana M, Hayashi, Katsuhiko, Shovlin, Tanya C, Mifsud, Will, Surani, M. Azim, McLaren††, Anne
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2008
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2233679/
https://www.ncbi.nlm.nih.gov/pubmed/18266475
http://dx.doi.org/10.1371/journal.pgen.0040030

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